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MONOGENIC DIABETES
REGISTRY OF INDIA

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Monogenic diabetes neonatal diabetes neonataldiabetes india maturity onset diabetes of youth MODY diabetes registry neonatal registry mody registry drmohans diabetes madras diabetes global diabetes Juvenile Diabetes

Maturity Onset Diabetes of Young (MODY)
 

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterized by autosomal dominant mode of inheritance, onset of non-insulin-dependent diabetes usually before 30 years of age, and reduced glucose-stimulated insulin secretion.

Clinical features:

  1. Age at onset of diabetes is <30 years
  2. Family history of diabetes in  one or both parents of the proband
  3. BMI   ≤ 30 (kg/m2)
  4. Correction of hyperglycaemia for a minimum period of 2 years without insulin.
  5. Absence of  ketonuria at any time
  6. Evidence of autosomal dominant inheritance

Significance of genetic testing:
MODY is often misdiagnosed as type 1 or type 2 diabetes (T2DM) as there is significant overlap in clinical features and hence the importance of genetic screening for MODY mutations. A genetic diagnosis of monogenic diabetes can have a significant impact on patient care.
Genes screened for MODY:

MODY is a heterogeneous group of diabetes caused by single gene defects in at least 13 genes affecting pancreas development and beta-cell function.

HNF4A (MODY 1) CEL (MODY 8)
GCK  (MODY 2) PAX4 (MODY 9)
HNF1A (MODY 3) INS (MODY 10)
IPF1 (MODY 4) BLK (MODY 11)
HNF1B (MODY 5) ABCC8 (MODY 12)
NEUROD1 (MODY 6) KCNJ11 (MODY 13)
KLF11 (MODY 7)  

Requirements for the genetic testing
Detailed clinical history along with blood/DNA samples from the patient, both parents and affected/unaffected siblings are required.

Consent Form
It is Mandatory to fill the concent form and send along with the sample.

Download MODY Registration Form | Online MODY Registration
 It is mandatory to fill this before any genetic testing has done.

 
 
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