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Monogenic diabetes neonatal diabetes neonataldiabetes india maturity onset diabetes of youth MODY diabetes registry neonatal registry mody registry drmohans diabetes madras diabetes global diabetes Juvenile Diabetes

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterized by autosomal dominant mode of inheritance, onset of non-insulin-dependent diabetes usually before 30 years of age, and reduced glucose-stimulated insulin secretion.

Clinical features:

1. Age at onset of diabetes is <30 years
2. Family history of diabetes in  one or both parents of the proband
3. BMI   ≤ 30 (kg/m2)
4. Correction of hyperglycaemia for a minimum period of 2 years without insulin.
5. Absence of  ketonuria at any time
6. Evidence of autosomal dominant inheritance

Significance of genetic testing:
MODY is often misdiagnosed as type 1 or type 2 diabetes (T2DM) as there is significant overlap in clinical features and hence the importance of genetic screening for MODY mutations. A genetic diagnosis of monogenic diabetes can have a significant impact on patient care.
Genes screened for MODY:

MODY is a heterogeneous group of diabetes caused by single gene defects in at least 13 genes affecting pancreas development and beta-cell function.

Requirements for the genetic testing
Detailed clinical history along with blood/DNA samples from the patient, both parents and affected/unaffected siblings are required.

Consent Form
It is Mandatory to fill the concent form and send along with the sample.

Download MODY Registration Form | Online MODY Registration
 It is mandatory to fill this before any genetic testing has done.